What is midazolam?
Midazolam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) sedative.
Midazolam is used to sedate a person who is having a minor surgery, dental work, or other medical procedure.
Midazolam may also be used for purposes not listed in this medication guide
Midazolam can slow or stop your breathing, especially if you have recently used a narcotic (opioid) medication. Midazolam is given in a hospital, dentist office, or other clinic setting where your vital signs can be watched closely.
You should not take midazolam if you have narrow-angle glaucoma, if you are allergic to cherries, or if you are allergic to midazolam or similar medicines (Valium, Xanax, Ativan, and others).
Do not drink alcohol for at least 24 hours after taking midazolam.
Before taking this medicine
You should not take midazolam if:
- you have narrow-angle glaucoma;
- you are allergic to cherries; or
- you are allergic to midazolam or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).
To make sure midazolam is safe for you, tell your doctor if you have:
- open-angle glaucoma;
- asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
- kidney or liver disease;
- congestive heart failure; or
- if you also use a narcotic (opioid) medication.
Midazolam can cause birth defects in an unborn baby, and generally should not be used during pregnancy. Tell your doctor if you are pregnant.
Midazolam can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take midazolam?
Midazolam can slow or stop your breathing, especially if you have recently used a narcotic (opioid) medication. Midazolam should be used only in a hospital, dentist office, or other clinic setting where any serious side effects can be quickly treated.
Midazolam is usually given as a single dose just before your surgery or procedure.
After you take midazolam, you will be watched closely to make sure the medicine is working and does not cause harmful side effects.
Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are in surgery.
Midazolam can make you very drowsy, dizzy, or light-headed. These effects may last longer in older adults. Use caution to avoid falling or accidental injury after you have received midazolam injection. You may need help getting out of bed for at least the first 8 hours.
What happens if I miss a dose?
Because you will receive midazolam in a clinical setting, you are not likely to miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of midazolam can be fatal.
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while taking midazolam?
Do not drink alcohol for at least 24 hours after taking midazolam. This medication can increase the effects of alcohol, which could be dangerous.
Grapefruit and grapefruit juice may interact with midazolam and lead to potentially dangerous effects. Avoid the use of grapefruit products while taking midazolam.
Midazolam injection can cause extreme drowsiness that may last for 24 hours after you have received the medication. Older adults may feel sleepy for even longer.
Avoid driving or doing anything that requires you to be awake and alert until the effects of midazolam have worn off completely.
Midazolam side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers right away if you have:
- cough, wheezing, trouble breathing, weak or shallow breathing;
- slow heart rate;
- a light-headed feeling, like you might pass out;
- agitation, hostility, tremors; or
- confusion, hallucinations, unusual thoughts or behavior.
The sedative effects of midazolam may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking midazolam.
Common side effects may include:
- amnesia or forgetfulness after your procedure;
- drowsiness, dizziness;
- nausea, vomiting;
- runny nose, sneezing; or
- blurred vision.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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